Gene: [12^/GSTMS1] glutathione S-transferase, microsomal, 1;

FUN

[1] Glutathione S-transferase participates in metabolism of various endogenous and exogenous hydrophobic substances. It has a wide substrate specificity.
[2] Systematic name: RX:glutathione R-transferase.
[3] The catalyzed reaction: RX + glutathione = HX + R-S-G."

MOP

In contrast to soluble glutathione transferases, the product of GSTMS1 gene functions better as a trimer."

EVO

Microsomal glutathione transferase gene differs drastically from other known GST genes in both nucleotide and amino acid sequences."

FAG

[1] Another gene encoding microsomal glutathione transferase is mapped to Chr 4: GEM:04q/GSTMS2. See also GEM:00.0/GSTMS3.
[2] On GST gene family and glutathione transferase classification, see FAM:GST/00.0."

REF

PRO,MOP,LOC,FAG,POL "DeJong JL &: Genomics, 6, N2, 379-382, 1990
PRO,MOP,LOC,FAG,POL "DeJong JL &: CCG, 51, (HGM10), 986, 1989
PRO,COD,MOP "DeJong JL &: JBC, 263, 8430-8436, 1988
CLO,SEQ,GEN "Kelner MJ &: Genomics, 36, 100-103, 1996
FUN,MEB "McLellan &: Biochem J, 258, N1, 87-93, 1989

SWI

SWISSPROT: P10620

KEY

xen, mem

CLA

coding, basic

LOC

12

MIM

MIM: 138330

EZN

ENZYME: 2.5.1.18

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